Pharmacokinetics and Pharmacodynamics of Warfarin Free Essay Example, 1000 words

Since warfarin is metabolized by hepatic cytochrome P-450 (CYP) isoenzymes predominately to inactive hydroxylated metabolites (excreted in the bile), warfarin metabolism may be altered in the presence of hepatic dysfunction or advanced age. It also is metabolized by reductases to reduced metabolites (warfarin alcohols), which are excreted by the kidneys. However, warfarin metabolism is not affected by renal impairment. (Stein JC, Olson KR, et al. This is because only small amounts of warfarin are excreted unchanged in urine. (Dewsbury C, 2003.After rapid intravenous or oral administration of an aqueous solution, warfarin has a distribution phase lasting 6 to 12 hours. The estimates of the volumes of distribution of R- and S-warfarin are similar to each other and to that of the racemate. Approximately 99% of the drug is bound to plasma proteins. The volume of distribution (VD), also known as apparent volume of distribution, is defined as the volume in which the amount of drug would need to be uniformly distributed to produce the observed blood concentration (Wikipedia). Warfarin has a VD of 8L, which reflects a high degree of plasma protein binding (Wikipedia). We will write a custom essay sample on Pharmacokinetics and Pharmacodynamics of Warfarin or any topic specifically for you Only $17.96 $11.86/page This prevents access to the sites of drug action, excretion, and metabolism. Therefore, warfarin sodium does not enter red blood cells, CSF is not present in the urine, and has a small volume of distribution that is identical to the albumin space.

Analysis Of Frankenstein By Mary Shelley - 1372 Words

In today’s technological society, one is constantly being judged based on one’s features, character, actions, and words. We are constantly bombarded with visuals and soundbites whether on social media or TV, causing many to pass judgement based on what we hear and see. When exposed, those assessments can leave one feeling negative, depressed, and angry. This may lead to violent behavior or the isolation of the person being criticized. Furthermore, one’s drive for personal success can get in the way of making good decisions. Hubris takes over and the need for both public and personal gratification usurps one’s morals, further isolating one from humanity. Although not in the technological age, the characters in Frankenstein by Mary Shelley, experience isolation due to bad choices or the opinions of society. Yet, the true evil in Frankenstein is not the characters, but isolation itself. When one is disengaged from family and society, egotism, violence, and revenge occur. Victor Frankenstein decides to abandon his family for six years in order to focus on his quest for glory. Frankenstein became focused on creating a scientific miracle that he isolates himself from his family and the rest of the world. This decision sets Frankenstein on a path of immorality and egotism. When Frankenstein’s best friend, Henry, arrives at the University of Ingolstadt where Victor studied, Henry immediately acknowledges Frankenstein’s lack of communication with his family, as he encourages VictorShow MoreRelatedAnalysis Of Frankenstein By Mary Shelley Essay1231 Words   |  5 Pages2016 Frankenstein Literary Analysis Power is the ability to control something or someone into doing what is given. Knowledge is the understanding of an idea, but not yet following through with it. You can have knowledge without power but the two combined usually result in a better outcome. Victor creates a monster which goes on rampages after they go separate ways. Because Victor originally left it and never later took control of it, unfortunate consequences occurred. In Frankenstein, by Mary ShelleyRead MoreAnalysis Of Frankenstein By Mary Shelley1755 Words   |  8 PagesFrankenstein An Analysis of the use of knowledge In the novel Frankenstein by Marry Shelley, it is apparent that a lack of knowledge along with an abundance of knowledge can lead to the destruction of relationships that are ideal for a happy life. The theme of corruption through knowledge is a recurring literary device throughout the novel. This corruption compels the reader to question whether or not it is beneficial to have the vast amount of knowledge that Victor has. Knowledge is a powerfulRead MoreAnalysis Of Mary Shelley s Frankenstein1411 Words   |  6 PagesIn the early 1800s Mary Shelley set pen to a paper and started to develop a novel that little to her knowledge would become world renowned. In 1818 she finished and published the novel to sell to the European public. The novel caught the world off guard in the way that a female was able to write about such harsh, dark, and evil things in a European society whose authors like John Locke and Charles Montesquieu preached enlightenment, self exploration, and individualism all in an optimistic enablingRead MoreAnalysis Of Mary Shelley s Frankenstein 1948 Words   |  8 PagesThere are many critical analyses to Mary Shelley’s Frankenstein. Two of these analyses bring forth varied interpretations. Sandra M. Gilbert and Susan Gubar wrote â€Å"Mary Shelley’s Monstrous Eve.† Anne K. Mellor wrote â€Å"Possessing Nature: The Female in Frankenstein.† Gilbert and Gubar argue that Mary Shelley wrote Frankenstein from the influence of her family in order to represent her personal life and life events. Mellor argues that the author wrote Frankenstein in order to represent many themes uponRead MoreAnalysis Of Mary Shelley s Frankenstein1615 Words   |  7 Pagesa whole and how accurate a depiction they might think it to be, they will miss out on many of the qualities of the painting that reside below the immediately apparent surface level. Mary Shelley’s Frankenstein is a text dedicated to expounding upon the dangers of such superficial analysis. In Frankenstein, Mary Shelley openly condemns the surface level and appearance oriented methodology under which the human mind operates. The very protagonist of the novel is inspired solely by reputation and howRead MoreAnalysis Of Mary Shelley s Frankenstein 1758 Words   |  8 PagesFrankenstein was published over 200 years ago. Ever since it was published, it has been one of the most famous books known to literature. History.com Staff states that this book, by 21-year-old Mary Wollstonecraft Shelley, is frequently called the world’s first science fiction novel (History.com Staff). According to Wikipedia, Shelley was an English novelist. She was born August 30th, 1797. She died on February 1st, 1951 (Wikipedia). Shelley came up with the idea of Frankenstein as she andRead MoreAnalysis Of Prometheus And Frankenstein By Mary Shelley Essay1996 Words   |  8 PagesPrometheus and Frankenstein both written in two different centuries I will show that our mentality hasn’t changes much in regards to monsters. While Prometheus and Frankenstein are, both consider monsters, Prometheus deals with trying to help humanity and Frankenstein deals with trying to find an understanding of why he was created. Both are considered monsters because of their actions. In the book Frankenstein by Mary Shelley, there is an article entitled Psychoanalytic Criticism and Frankenstein. In thisRead MoreAnalysis Of Frankenstein By Mary Shelley1449 Words   |  6 PagesDuality Makes The Man: What It Takes to Be Human in Frankenstein In her nineteenth century novel Frankenstein, Mary Shelley explores the characteristics of humanity, illuminates societal influences on development, and challenges the traditional biological definition of human through character developments and interactions. Particularly, she focuses on the characterization of the creature and his creator, pitting an ugly, malformed giant against an educated, dedicated scientist to establish a surprisingRead MoreAnalysis Of Frankenstein By Mary Shelley1590 Words   |  7 PagesIn this sense, she was actually quite similar to Frankenstein’s monster from the novel, Frankenstein, by Mary Shelley. The monster is brought to life by Victor Frankenstein only to be abandoned moments after his creation. Desperate to find companionship and make sense of the world, the monster ventures off on his own, only to be shunned by society because of â€Å"hideous† appearance and â€Å"gigantic† stature (Shelley). Miserably alone in a cruel wor ld, the monster extracts his revenge on his creator by killingRead MoreAnalysis Of Mary Shelley s Frankenstein Essay2155 Words   |  9 Pagesmain agenda could orchestrate catastrophic repercussions to the human populations. Mary Shelley’s work â€Å"Frankenstein† although over two-hundred years old, remains at the pinnacle of irresponsible innovation that wreaks havoc to the human population. In the â€Å"Jurassic Park,† an aspect of mad science that deteriorates the stability of life is depicted. Both Michael Clinton’s â€Å"Jurassic Park† and Mary Shelley’s â€Å"Frankenstein† extensively explore the role of man in maintaining and sustaining life. The two

Stable Sociocultural Code of Governmental †MyAssignmenthelp.com

Question: Discuss about the Stable Sociocultural Code of Governmental. Answer: Introduction: In the given case study, the company Job for You has been facing a situation, claimed by the employees that they are facing unfairly terminated and mistreated. The employees filed case against the company. Since the employee appealed to view their own records to the national privacy legislation, it was difficult for the company to keep the records safely in their database. The company newly introduces a Recruitment Manager, Stella to devise set of codes for privacy purpose of the company. Keeping in mind the ethical and professional value that the company instructed there are five essential set of policies that are required to be followed: Understanding the Employment at Will Policy: The choice of embracing a "independently" work strategy, implying that a business may fire any worker whenever, for any reason, or for reasons unknown by any means. Now and again worker understandings or contracts negate the "voluntarily" strategy, so checking the words to ensure where one stands. Know the circumstances when it is illegal to fire an Employee: There are limitation, like the below issues: Whistleblowers- Employees cannot be fired for complaining about illegal activities in the workplace, violation in health and safety or harassment in the workplace. Discrimination- Employees are prevented by Federal anti-discrimination laws from firing the employees based on religion, race, age, gender or disability. Exercising Legal Rights- Taking required leave family or medical leave, serve on a jury or time off to vote does not allow the organization to fire the employees. Being sure to Document the Performance Issues: Cases of poor execution in the workplace and lateness and keeping up great records of worker execution surveys and any past disciplinary intercessions. These will give authenticity to ones activities and keep any objection, claim or allegations that may end were biasig the situation. Understand Employee Rights-Benefits and Unemployment Insurance: Continuation of Health Insurance Coverage COBRA is a federal law Unemployment Insurance Vested Retirement Plans Thus, this set of codes will help Jobs for You to record notes about the workers without being afraid of being sued by the employees. References Wood, R. J. (2016). Family Tax Law: Improving the Organization of the Internal Revenue Code by Creating a Subdivision on Family Tax Law. Quinnipiac L. Rev., 35, 243. Lyubashits, V. Y., Mamychev, A. Y., Vronskaya, M. V., Timofeeva, A. A. (2015). Order as Stable Sociocultural Code of Governmental Organization: Formation History and Modern Interpretations. Mediterranean Journal of Social Sciences, 6(6 S3), 198. Herbst, J. (2017). Using a systems perspective to teach introduction to machine organization with laboratory. Journal of Computing Sciences in Colleges, 32(6), 189-191. Efanov, D., Sapozhnikov, V., Sapozhnikov, V. (2016, October). Methods of organization of totally self-checking concurrent error detection system on the basis of constant-weight 1-out-of-3-code. In East-West Design Test Symposium (EWDTS), 2016 IEEE (pp. 1-9). IEEE.

Only God Can Judge Me free essay sample

That’s why police didn’t tried to accuse her killing her own husband. In the story we truly understand the significant of the expression, don’t judge a book by its cover. Police officers never intended to accuse Mary Maloney of murdering her husband. Mary Maloney looking innocent, acting like she never do anything, and made up a fake story to draw away suspicious from her. After she killed Patrick Maloney by hitting him with the leg of the lamb, she was nervous and afraid that the police will know she slaughtered her own husband just because she do not want Patrick to leaver her. That’s why Mary Maloney turned evil and hit Patrick with the leg of lamb. After she smash him, Mary was afraid that police will take her but she figured out a plan to draw away suspicious. In the text, after savage Patrick, â€Å" All the love for him came back to her and she ran over to him, knelt down beside him, and began to cry hard. We will write a custom essay sample on Only God Can Judge Me or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page It was easy. No acting necessary. † (Dahl,4) This quote means that she planned everything acting like she was gone the all time to draw suspicious so police would not accuse her. People in the outside are not the same in the inside because in the outside doesn’t give you a lot of information but the inside part does. It is like a book, the book might have a boring caption or title but when you read it, it is good and interesting. When all the police officers, detective started to come, Mary Maloney still acted like an honesty women and tried to be nice so they would not tried to blame her because the way she treat them, asking if they thirsty and offering food to eat. In the text it says, â€Å"The ean searching the rooms were getting tired, â€Å"Jack†, she said, â€Å" Would you like a drink? You must be extremely tired. † (Dahl, 4) This qoute means that she was trying to be nice so they would not accuse her or tried to blame from killing Patrick. Mary Maloney is really evil person on this part because she really thought a good excuses so they will not accuse her. Looks are really deceiving. Don’t mistaken someones personality b ased on how they look and act because look are not their personality. Only what inside of them tells you who really they are and what their personality is. According to the text, officers mistaken personality based on how Mary Maloney looks because Mary was crying and tearing that she was shock that her husband got assassinated. It says in the text, â€Å" Is he dead, she cried. † (Dahl, 4) Police would never accused a person who is there acting like she cared about what happen. So we should not get confused based on how people act and dress on the outside because we don’t know if their just faking it. Since people this day are two fake faces. And it means that they have two face that are fake; one are being really but fake in inside and the other one is just being itself, fake person. So don’t get attract just because their nice in outside because their outside doesn’t mean anything. In conclusion, we should not judge people by how they dress, look and act on outside of them because that is not who really they are. We need to be in their inside before start judging. We need to know the person better before we start accusing anything on them because judging not knowing who really they are isn’t right. Its really bad thing to judge people who you really don’t know and plus your just proving yourself that your a really hater. Also don’t judge a person base on stereotype.